| Hogyu
HAN |
 |
| ADDRESS |
| Department of Chemistry, Korea University,
Seoul 136-701, KOREA |
| TEL
|
| 82-2-3290-3134 |
| FAX
|
| 82-2-3290-3121 |
| E-MAIL
|
| hogyuhan@kuccnx.korea.ac.kr |
|
| Research
Area |
|
Research conducted in this laboratory is classified
into three areas. We try to synthesize crystals of biomolecules
in a programed manner by using deoxyribonucleotide (DNA)
as a periodic crystallization template and DNA binding
molecules as a vehicle for arranging proteins and nucleic
acids on DNA crystals. We are also interested in design,
synthesis and characterization of organic molecules
useful for regulating and sensing activities of biomolecules
and thus for understanding biological processes at a
molecular level. Finally, we are in quest of general
methodologies applicable to chemical synthesis of proteins
with more than 200 amino acids and/or site-specific
modifications such as glycosylation and phosphorylation.
|
| Selected
Publications |
1.
"The core Alzheimer's peptide NAC forms amyloid fibrils
which seed and are seeded by ет-amyloid: is NAC a common
trigger or target in neurodegenerative disease?", Han,
H.; Weinreb, P. H.; Lansbury, P. T., Jr. Chemistry and
Biology 1995, 2, 163-169.
2. "Amyloid probes based on Congo Red
distinguish between fibrils comprising different peptides",
Ashburn, T. T.; Han, H.; McGuinness, B. F.; Lansbury,
P. T., Jr. Chemistry and Biology 1996, 3, 351-358.
3. "Technetium complexes for the quantitation
of brain amyloid", Han, H.; Cho, C.; Lansbury, P. T.,
Jr. J. Am. Chem. Soc. 1996, 118, 4506-4507. |
|
